Preparation of leustroducsin H and the structure-activity relationship of its derivatives.
نویسندگان
چکیده
enzymatically prepared by removing acyl moieties from the cyclohexane ring of LSNs, and its thrombopoietic effects. Furthermorewealso report on the structureactivity relationship of its derivatives. A mixture of LSNswas treated with porcine liver esterase (PLE-A) in acetone-phosphate buffer (pH = 6.7) at 37°C, after filtering off the enzyme, purification by Cosmosil column afforded LSN-H (Id) along with small amount of alcohol 2. The hydrolysis to yield Id only indicated that all LSNs have the same absolute configuration. The absolute configuration of LSN-H was determined to be 4S, 5S9 SR, 9R, UR, 16R, 18S.6) N-acetyl LSN-H (3a) was synthesized by treating LSN-H with N-methoxydiacetamide in methanol. Compounds 3b~31 were prepared by treating LSN-H
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 48 12 شماره
صفحات -
تاریخ انتشار 1995